In 1898, Marie and Pierre Curie discovered radium. In 1928, the world’s first antibiotic—Penicillin—was discovered. In 1960, the deepest part of the ocean was explored. The human genome was sequenced in 2003. In 2006, 73 years after it was discovered, Pluto was downgraded to a “dwarf planet.” These are some of the landmark moments in the history of science that PopSci’s video producer Tom McNamara charts in his delightful three-minute compilation of what has happened since the magazine was first published in 1872.

Read more about Marie Curie, deep-sea exploration, and DNA on Sloan Science & Film.