Something is attacking the rural population of a small southern fishing Town. Dr. Courtney Greer, the brilliant but quick-tempered government expert on invasive species, swoops down from Washington DC to investigate. Her "ace" team is, unfortunately, less than ideal: a suicidial ichthyologist, a singing toxicologist and a sexually confused ecologist. Courtney herself suffers from baffling stress-induced hallucinations. Despite their idiosyncrasies, the team must get their act together when Courtney discovers that the town's largest lake is infested with deadly snakefish. Not only do these predatory creatures carry an incurable disease that could devastate North America's ecosystem, but their recent spawning has exponentially increased their numbers, giving them greater opportunities to kill. With less than twenty-four hours before the brood will migrate into America's river system and, thus, contaminate the entire country, Courtney and her team must work around the clock to find and destroy all the snakefish. When Courtney discovers their hidden breeding ground, she alone must go face to face against the snakefish if she is to save not only herself but also all of America.