NASA has finally pinpointed the place mostly likely to contain life on Mars. A spider-like rover is set loose to explore the likely cave. But with the rover comes a fast spreading contaminant that threatens to destroy any hint of life. Astronaut Sam Mann and Astrophysicist Anna Beeman team up to destroy the contaminant. Once on Mars, Sam and Anna put theory to test and find themselves struggling to save each other while trying to save life on the red planet.